Targeted degradation of oncogenic KRASG12V triggers antitumor immunity in lung cancer models.

求助中 10 由 TT 发布于 2024/12/28 23:45:11

DOI:10.1172/JCI174249
作者：Dezhi Li,?Ke Geng,?Yuan Hao,?Jiajia Gu,?Saurav Kumar,?Annabel T Olson,?Christina C Kuismi,?Hye Mi Kim,?Yuanwang Pan,?Fiona Sherman,?Asia M Williams,?Yiting Li,?Fei Li,?Ting Chen,?Cassandra Thakurdin,?
文献类型：期刊论文
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Journal of Clinical Investigation (JCI)

Abstract：KRAS is the most frequently mutated oncogene in lung adenocarcinoma, with G12C and G12V being the most predominant forms. Recent breakthroughs in KRASG12C inhibitors have transformed the cli

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