Vasculitis and the NLRP3 inflammasome.

IF 5.2 2区医学 Q1 RHEUMATOLOGY Current opinion in rheumatology Pub Date : 2024-01-01 Epub Date: 2023-08-13 DOI:10.1097/BOR.0000000000000962

Kamel Hamzaoui, Agnès Hamzaoui

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Abstract

Purpose of review: Vasculitis are a group of heterogeneous conditions characterized by chronic inflammation of blood vessels, leading to tissue destruction and organ failure. Vasculitis is an inflammatory process in which immune effector cells infiltrate blood vessels and surrounding tissues. The involvement of inflammasomes seems to occur during inflammatory processes.

Recent findings: Studies have emphasized that genetic susceptibility is an important aspect of the pathogenesis of vasculitis. The innate immune system is a major contributor to these inflammatory diseases, suggesting that the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome plays a key role. NLRP3 activation causes the assembly of a large multiprotein and leads to the secretion of bioactive interleukin (IL)-1β and IL-18 as well as the induction of inflammatory cell death, termed pyroptosis. Accumulating evidence confirms the involvement of this cascade in sterile inflammatory diseases and other vascular diseases.

Summary: In this review, we will summarize the current state of knowledge regarding the role of NLRP3 inflammasome in vascular diseases, and discuss the potential of the NLRP3 inflammasome as a therapeutic target.

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血管炎和NLRP3炎性体。

综述目的:血管炎是一组以血管慢性炎症为特征的异质性疾病，可导致组织破坏和器官衰竭。血管炎是免疫效应细胞浸润血管和周围组织的炎症过程。炎性小体的参与似乎发生在炎症过程中。最新发现:研究强调遗传易感性是血管炎发病机制的一个重要方面。先天免疫系统是这些炎症性疾病的主要诱因，这表明含有3 (NLRP3)炎症小体的nod样受体家族pyrin结构域起关键作用。NLRP3的激活导致大量多蛋白的聚集，导致生物活性白介素(IL)-1β和IL-18的分泌，并诱导炎症细胞死亡，称为焦亡。越来越多的证据证实这种级联反应参与无菌性炎症性疾病和其他血管疾病。摘要:在这篇综述中，我们将总结NLRP3炎性小体在血管疾病中的作用，并讨论NLRP3炎性小体作为治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in rheumatology 医学-风湿病学

CiteScore

9.70

自引率

2.00%

发文量

审稿时长

6-12 weeks

期刊介绍： A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.

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