A paradigm of higher success rate of intracytoplasmic sperm injection - preovulatory human chorionic gonadotropin-day serum oestradiol.

IF 2.5 Q2 OBSTETRICS & GYNECOLOGY Przeglad Menopauzalny Pub Date : 2023-06-01 DOI:10.5114/pm.2023.127964

Ahmed Elsayad, Wael Khafagy, Walaa ElBassioune, Mahmoud Rady, Ahmed Abdeltawab, Muhammad Altoraky, Mahmoud Hegazy, Waled Ayad, Moatazza Alghazaly, Ahmed Elshorbagy, Ahmed Shafik Almorsy, Ahmed Saeed, Elmetwally Farouk, Ehab Elhelw, Hamada Abuelmatti, Mohammed El-Husseny Elkadosi

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Abstract

Introduction: The aim of the study is to evaluate the correlation between the level of serum oestradiol (E₂) on the day of human chorionic gonadotropin (hCG-day) administration and successful intracytoplasmic sperm injection (ICSI) outcome.

Material and methods: This prospective study was performed during the period from January 2019 to September 2021, at Zagazig Obstetrics and Gynecology Department, and Al-Azhar Obstetrics and Gynecology Department, and private ART centers. One hundred and fifty women attending the infertility clinic for ICSI cycles. All women were divided into 5 groups according to the serum E₂ level on the day of hCG administration: Group A - serum E₂ < 1000 pg/ml; Group B - serum E₂ 1000 to < 2000 pg/ml; Group C - serum E₂ 2000 to < 3000 pg/ml;Group D - serum E₂ 3000 to < 4000 pg/ml; Group E - serum E₂ ≥ 4000 pg/ml.

Results: The highest fertilization rate (58.1%) was among women with E₂ ≥ 4000 pg/ml, while the lowest (37%) was in women with E₂ 1000 to < 2000 pg/ml. Also, the highest pregnancy rate (21.5%) was among women with E₂ > 4000 pg/ml, while the lowest (5.3%) was in women with E₂ < 1000 pg/ml. In the current study the median serum E₂ level on the day of hCG administration was highly significant in women who became pregnant when compared to women who did not. The best cut-off value of serum E₂ at hCG administration was ≥ 3682.3 pg/ml.

Conclusions: this study suggests that the optimal range of E₂ level for achieving a successful pregnancy is > 4000 pg/ml.

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卵泡内单精子注射高成功率的范例-排卵前人绒毛膜促性腺激素日血清雌二醇。

前言:本研究的目的是评估人绒毛膜促性腺激素(hCG-day)给药当天血清雌二醇(E2)水平与成功的卵浆内单精子注射(ICSI)结果之间的相关性。材料和方法:本前瞻性研究于2019年1月至2021年9月在Zagazig妇产科和Al-Azhar妇产科以及私立ART中心进行。150名妇女在不孕不育诊所接受ICSI周期。根据给药当日血清E2水平分为5组:A组-血清E2 < 1000 pg/ml;B组:E2 1000 ~ < 2000 pg/ml;C组血清E2 2000 ~ < 3000 pg/ml; D组血清E2 3000 ~ < 4000 pg/ml;E组-血清E2≥4000 pg/ml。结果:E2≥4000 pg/ml受精率最高(58.1%)，E2 1000 ~ < 2000 pg/ml受精率最低(37%)。E2 > 4000 pg/ml的孕妇妊娠率最高(21.5%)，E2 < 1000 pg/ml的孕妇妊娠率最低(5.3%)。在目前的研究中，与未怀孕的妇女相比，怀孕妇女在服用hCG当天的血清E2水平中位数非常显著。给药时血清E2的最佳临界值为≥3682.3 pg/ml。结论:本研究提示E2水平的最佳范围为> 4000 pg/ml。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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