María Teresa Miras Portugal: a pioneer for vesicular nucleotide storage.

IF 3 4区医学 Q2 NEUROSCIENCES Purinergic Signalling Pub Date : 2024-04-01 Epub Date: 2022-12-16 DOI:10.1007/s11302-022-09912-z

Yoshinori Moriyama, Nao Hasuzawa, Masatoshi Nomura

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Abstract

Chromaffin granules are secretory granules present in adrenal medulla chromaffin cells. They contain high contents of catecholamines and nucleotides and have been regarded as a model system for the study of vesicular transmitter uptake and release. In 1988, Dr. María Teresa Miras Portugal, when studying catecholamine biosynthesis, detected a novel group of nucleotides, the diadenosine polyphosphates, in the adrenal chromaffin granules. Based on this finding, she unraveled the existence of diadenosine polyphosphate-mediated chemical transmission, leading to a paradigm shift in the field of purinergic signaling. She is also a pioneer in the studies on vesicular nucleotide storage. First, María Teresa and her group characterized nucleotide transport in chromaffin granules and synaptic vesicles using fluorescent nucleotide derivatives such as 1, N6-ethenoadenosine triphosphates. Then, they revealed the presence of a hypothetical vesicular nucleotide transporter with unique properties in terms of substrate specificity. In this article, we will describe her contributions to vesicular nucleotide storage and the foundations she laid for future studies.

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玛丽亚-特雷莎-米拉斯-葡萄牙：囊泡核苷酸储存的先驱。

色素颗粒是存在于肾上腺髓质绒毛细胞中的分泌颗粒。它们含有大量儿茶酚胺和核苷酸，一直被视为研究囊泡递质摄取和释放的模型系统。1988 年，玛丽亚-特雷莎-米拉斯-葡萄牙博士在研究儿茶酚胺的生物合成时，在肾上腺绒毛膜颗粒中发现了一组新的核苷酸--二腺苷多磷酸盐。基于这一发现，她揭示了由多磷酸二腺苷介导的化学传递的存在，导致了嘌呤能信号领域的范式转变。她还是研究囊泡核苷酸储存的先驱。首先，玛丽亚-特雷莎和她的研究小组利用荧光核苷酸衍生物（如 1，N6-乙烯腺苷三磷酸酯）鉴定了嗜铬细胞颗粒和突触小泡中核苷酸的运输。随后，他们发现了一种假定的囊泡核苷酸转运体，这种转运体在底物特异性方面具有独特的特性。在本文中，我们将介绍她对囊泡核苷酸储存的贡献以及她为未来研究奠定的基础。

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来源期刊

Purinergic Signalling 医学-神经科学

CiteScore

6.60

自引率

17.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Nucleotides and nucleosides are primitive biological molecules that were utilized early in evolution both as intracellular energy sources and as extracellular signalling molecules. ATP was first identified as a neurotransmitter and later as a co-transmitter with all the established neurotransmitters in both peripheral and central nervous systems. Four subtypes of P1 (adenosine) receptors, 7 subtypes of P2X ion channel receptors and 8 subtypes of P2Y G protein-coupled receptors have currently been identified. Since P2 receptors were first cloned in the early 1990’s, there is clear evidence for the widespread distribution of both P1 and P2 receptor subtypes in neuronal and non-neuronal cells, including glial, immune, bone, muscle, endothelial, epithelial and endocrine cells.