Macimorelin Acetate for the Diagnosis of Childhood-onset Growth Hormone Deficiency.

Rohan K Henry
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Abstract

Growth hormone provocation testing forms the cornerstone of the diagnosis of childhood growth hormone deficiency in clinical practice. Despite the widespread use of these tests, various criticisms have been levelled against them, such as the labour-intensive nature of the tests, their potential for serious adverse effects and their questionable reproducibility. Macimorelin acetate, a ghrelin mimetic approved for the diagnosis of adult growth hormone deficiency, could serve an unmet need in the diagnosis of childhood-onset growth hormone deficiency based on its good tolerability and benign side effect profile.

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醋酸马西莫瑞林对儿童期生长激素缺乏症的诊断价值。
生长激素激发试验是临床诊断儿童生长激素缺乏症的基础。尽管这些测试被广泛使用,但对它们提出了各种批评,例如测试的劳动密集性、可能产生严重不利影响以及可重复性值得怀疑。醋酸马西莫瑞林(Macimorelin acetate)是一种被批准用于诊断成人生长激素缺乏症的促生长素仿物,由于其良好的耐受性和良性副作用,可以满足儿童发病生长激素缺乏症的诊断需求。
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