Advances and Emerging Therapies in the Treatment of Non-alcoholic Steatohepatitis.

Paul N Brennan, John F Dillon, Rory McCrimmon
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引用次数: 1

Abstract

Non-alcoholic steatohepatitis (NASH) now represents one of the most prevalent forms of cirrhosis and hepatocellular carcinoma. A number of treatment agents have undergone assessment in humans following promising results in animal models. Currently, about 50 therapeutic agents are in various stages of development. Recently, however, there have been a number of exciting and positive developments in this landscape, although there are inherent challenges ahead. In this article, we review the aetiological and pathological basis of NASH progression and describe putative targets for current therapies. We also discuss some of the likely future directions and difficulties around this complex and challenging disease paradigm.

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非酒精性脂肪性肝炎治疗的进展和新疗法。
非酒精性脂肪性肝炎(NASH)现在是肝硬化和肝细胞癌最常见的形式之一。在动物模型取得令人满意的结果后,一些治疗药物已在人类身上进行了评估。目前,大约有50种治疗药物处于不同的开发阶段。然而,最近在这方面出现了一些令人兴奋和积极的事态发展,尽管前面存在着固有的挑战。在本文中,我们回顾了NASH进展的病因和病理基础,并描述了当前治疗的假定靶点。我们还讨论了围绕这种复杂和具有挑战性的疾病范式的一些可能的未来方向和困难。
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