Towards a better understanding of non-exudative choroidal and macular neovascularization

IF 18.6 1区 医学 Q1 OPHTHALMOLOGY Progress in Retinal and Eye Research Pub Date : 2023-01-01 DOI:10.1016/j.preteyeres.2022.101113
Riccardo Sacconi , Serena Fragiotta , David Sarraf , SriniVas R. Sadda , K. Bailey Freund , Mariacristina Parravano , Giulia Corradetti , Diogo Cabral , Vittorio Capuano , Alexandra Miere , Eliana Costanzo , Francesco Bandello , Eric Souied , Giuseppe Querques
{"title":"Towards a better understanding of non-exudative choroidal and macular neovascularization","authors":"Riccardo Sacconi ,&nbsp;Serena Fragiotta ,&nbsp;David Sarraf ,&nbsp;SriniVas R. Sadda ,&nbsp;K. Bailey Freund ,&nbsp;Mariacristina Parravano ,&nbsp;Giulia Corradetti ,&nbsp;Diogo Cabral ,&nbsp;Vittorio Capuano ,&nbsp;Alexandra Miere ,&nbsp;Eliana Costanzo ,&nbsp;Francesco Bandello ,&nbsp;Eric Souied ,&nbsp;Giuseppe Querques","doi":"10.1016/j.preteyeres.2022.101113","DOIUrl":null,"url":null,"abstract":"<div><p>Non-exudative macular and choroidal neovascularization<span> (MNV and CNV) usually refers to the entity of treatment-naïve type 1 neovascularization in the absence of associated signs of exudation. Histopathological studies, dating back in the early 70s, identified the presence of non-exudative MNV, but the first clinical report of this finding was in the late 90s using indocyanine green angiography<span><span> in eyes with age-related macular degeneration (AMD). With more advanced retinal imaging, there has been an ever increasing appreciation of non-exudative MNV associated with AMD and CNV with other </span>macular disorders<span>. However, consensus regarding the exact definition and the clinical management of this entity is lacking. Furthermore, there may be variation in the imaging features and clinical course suggesting that a spectrum of disease may exist. Herein, we review the large body of published work that has provided a better understanding of non-exudative MNV and CNV in the last decade. The prevalence, multimodal imaging<span> features, clinical course, and response to treatment are discussed to elucidate further key insights about this entity. Based on these observations, this review also proposes a new theory about the origin and course of different sub-types of non-exudative MNV/CNV which can have different etiologies and pathways according to the clinical context of disease.</span></span></span></span></p></div>","PeriodicalId":21159,"journal":{"name":"Progress in Retinal and Eye Research","volume":null,"pages":null},"PeriodicalIF":18.6000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Retinal and Eye Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1350946222000738","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 12

Abstract

Non-exudative macular and choroidal neovascularization (MNV and CNV) usually refers to the entity of treatment-naïve type 1 neovascularization in the absence of associated signs of exudation. Histopathological studies, dating back in the early 70s, identified the presence of non-exudative MNV, but the first clinical report of this finding was in the late 90s using indocyanine green angiography in eyes with age-related macular degeneration (AMD). With more advanced retinal imaging, there has been an ever increasing appreciation of non-exudative MNV associated with AMD and CNV with other macular disorders. However, consensus regarding the exact definition and the clinical management of this entity is lacking. Furthermore, there may be variation in the imaging features and clinical course suggesting that a spectrum of disease may exist. Herein, we review the large body of published work that has provided a better understanding of non-exudative MNV and CNV in the last decade. The prevalence, multimodal imaging features, clinical course, and response to treatment are discussed to elucidate further key insights about this entity. Based on these observations, this review also proposes a new theory about the origin and course of different sub-types of non-exudative MNV/CNV which can have different etiologies and pathways according to the clinical context of disease.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
为了更好地了解非渗出性脉络膜和黄斑新生血管
非渗出性黄斑和脉络膜新生血管(MNV和CNV)通常是指在没有相关渗出体征的情况下treatment-naïve 1型新生血管的实体。早在70年代早期的组织病理学研究就发现了非渗出性MNV的存在,但这一发现的第一个临床报告是在90年代末使用靛绿血管造影术对患有年龄相关性黄斑变性(AMD)的眼睛进行的。随着视网膜成像技术的发展,与AMD相关的非渗出性MNV和与其他黄斑疾病相关的CNV越来越受到重视。然而,关于这个实体的确切定义和临床管理的共识是缺乏的。此外,在影像学特征和临床病程上可能存在差异,表明可能存在疾病谱系。在此,我们回顾了在过去十年中提供了对非渗出性MNV和CNV更好理解的大量已发表的工作。患病率,多模态影像特征,临床过程和治疗反应进行了讨论,以阐明进一步的关键见解关于这个实体。基于这些观察结果,本文还提出了关于非渗出性MNV/CNV不同亚型的起源和病程的新理论,这些亚型根据疾病的临床背景可能具有不同的病因和途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
34.10
自引率
5.10%
发文量
78
期刊介绍: Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists. The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.
期刊最新文献
Dual inheritance patterns: a spectrum of non-syndromic inherited retinal disease phenotypes with varying molecular mechanisms. Eye on the horizon: The metabolic landscape of the RPE in aging and disease Standard automated perimetry for glaucoma and diseases of the retina and visual pathways: current and future perspectives. Pathobiology of the crystalline lens in Stickler syndrome AI in the clinical management of GA: A novel therapeutic universe requires novel tools
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1