The Effect of Clofibrate and Phototherapy on Prolonged Jaundice due to Breast Milk in Full-Term Neonates.

IF 1.7 Q2 PEDIATRICS Clinical Medicine Insights-Pediatrics Pub Date : 2023-01-01 DOI:10.1177/11795565231177987
Fatemeh Eghbalian, Roya Raeisi, Javad Faradmal, Amin Asgharzadeh
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引用次数: 1

Abstract

Introduction: Jaundice is one of the most common problems during infancy. It is believed that breast milk jaundice is one of the reasons for the persistence of jaundice after 14 days of prolonged jaundice. This study evaluates the effect of Clofibrate and phototherapy on prolonged jaundice originating from breast milk in term and healthy neonates.

Materials and methods: This double-blind clinical trial study was performed on 100 randomly divided neonates in the neonatal ward of Besat Hospital. In addition to phototherapy, the case group received a single dose of edible Clofibrate (50 mg/kg) dissolved in 2 CCs of distilled water. The control group received the same amount of distilled water as the phototherapy group. After treatment, bilirubin change rate, duration of hospitalization, and any association with gender, gestational age, hemoglobin, blood type, and Rh of neonates were determined and compared throughout the 2 groups.

Results: Data analysis showed that the bilirubin reduction rate was statistically significantly higher in the case group than in the control group (P < .05). The mean duration of hospitalization and phototherapy in the case group was significantly lower than in the control group (P = .005). The bilirubin reduction rate was not affected significantly by gestational age, blood type, or Rh.

Conclusion: This study's results demonstrated that Clofibrate effectively decreased bilirubin levels and shortened the duration of phototherapy and hospitalization in infants with probable breast milk jaundice.

Registration: IRCT2012092910933N1.

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氯贝酸钠与光疗对足月新生儿母乳所致延长性黄疸的影响。
黄疸是婴儿期最常见的问题之一。认为母乳黄疸是黄疸持续14天后持续的原因之一。本研究评估了氯贝特和光疗对足月和健康新生儿源于母乳的长期黄疸的影响。材料与方法:本双盲临床试验研究在贝萨特医院新生儿病房随机分组的100例新生儿中进行。除光疗外,病例组接受单剂量(50 mg/kg)溶解于2cc蒸馏水中的食用氯贝特。对照组给予与光疗组等量蒸馏水。治疗后比较两组患者胆红素变化率、住院时间以及与新生儿性别、胎龄、血红蛋白、血型、Rh的关系。结果:资料分析显示,病例组胆红素降低率显著高于对照组(P P = 0.005)。胆红素降低率不受胎龄、血型或Rh的显著影响。结论:本研究结果表明,氯贝特能有效降低可能患有母乳黄疸的婴儿的胆红素水平,缩短光疗和住院时间。注册:IRCT2012092910933N1。
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