Nitric Oxide Level Estimation in Patients of Oral Lichen Planus in Kashmiri Population – An Original Research

Abstract

Introduction: Oxidative stress and antioxidant defense mechanism may play an important role in the pathology of lichen planus. Objectives: Evaluate the levels of NO in serum of patients with OLP and to compare the levels with the controls.  Material and Methods: The study included 30 cases of OLP patients which formed the study group and 30 cases of healthy individuals, which formed the controls.  Results: The levels of NO were significantly higher in serum of cases with lichen planus than in normal. Conclusion: Serum NO were found to be higher in oral lichen planus patients which suggested that higher serum levels of NO in patients with OLP might activate the process of lymphocytes and cellular immunity system; hence, possibly endorsing the effect of serum NO in pathogenesis of lichen planus.