[Participation of some nucleotides in regulation of phosphoprotein phosphates activity in rat and chicken myocardium].

Ukrains'kyi biokhimichnyi zhurnal Pub Date : 1977-05-01
G K Parsadanian, I G Aslanian, L P Ter-tatevosian
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Abstract

Adenine- and uridine di- and triphosphates (in a 3 mM concentration) increase considerably phosphoprotein phosphatase (PPPase) (EC 3.1.3.16) activity of rat and chicken myocardium homogenates. AMP and Pi are effective inhibitors of the enzyme. The ATP activating effect is also shown in partially purified preparations of rat myocardium PPPase. ATP is able of protecting significantly the enzyme during its thermodenaturation.

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[一些核苷酸参与调节大鼠和鸡心肌中磷酸蛋白的活性]。
腺嘌呤和尿嘧啶二磷酸和三磷酸(浓度为3 mM)可显著提高大鼠和鸡心肌匀浆中磷酸蛋白磷酸酶(PPPase) (EC 3.1.3.16)的活性。AMP和Pi是这种酶的有效抑制剂。在部分纯化的大鼠心肌PPPase制剂中也显示出ATP激活作用。ATP在酶的热变性过程中起着重要的保护作用。
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