Christiane Baumgartl-Simons, Christiane D. Hohensee
{"title":"How Can the Final Goal of Completely Replacing Animal Procedures Successfully Be Achieved?","authors":"Christiane Baumgartl-Simons, Christiane D. Hohensee","doi":"10.1163/9789004391192_004","DOIUrl":null,"url":null,"abstract":"2373. [ online] Available at: https:/ /www.mattek.com/reference-library/ identification-of-endocrine-disruptors-using-an-organotypic-vaginal-tissue model/ [Accessed 6 August 2017 ]. Ayehunie, S., Landry, T., Hayden, P. and Klausner M. ( 2016 ). Pre-validation of in vitro in vivo assays for vaginal irritation. In: Society of Toxicology 2016 Annual Meeting. [ online] Available at: https:/ /www.mattek.com/join-us-at-sot-2016/ [ Accessed 6 August 2017 ] . Baumgartl-Simons, C. (2017). Das Ende muss endlich wirksam verfolgt werden. Tierrechte, 02, p. 4. [ online] Available at: https:/ /www.tierrechte.de/images/stories/ Presse_und_Magazin_Tierrechte/Magazin_2-17 _.pdf [ Accessed nJanuary 2018] . BfR(2017a) .NationalerAusschussTierschutzgesetz-EJR. [ online ]Availableat:http:/ /www .bfr.bund.de/ de/nationaler_ausschuss_tierschutzgesetz.html [ Accessed 2 August 2017] . Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access 116 BAUMGARTL-SIMONS AND HOHENSEE BfR (2017b). Fragen und Antworten zum Deutschen Zentrum zum Schutz von Versuch stieren (B/3R). [ online] Available at: http://www.bfr.bund.de/cm/343/fragen-und antworten-zum-deutschen-zentrum-zum-schutz-von-versuchstieren-bf3r.pdf [ Accessed 4 August 2017 ] . BMBF (20n). Bekanntmachung des Bundesministeriums far Bi/dung und Forschung von Richtlinien zur Forderung ,,e:Bio lnnovationswettbewerb Systembiologie\" Vom 17. Dezember 2010. [ online] Available at: https:/ /www.bmbf.de/foerderungen/ bekanntmachung.php?B=6o8 [ Accessed 4 August 2017 ] . BMBF (2015a). Bekanntmachung des Bundesministeriumsfar Bildung und Forschung von Richtlinien zur Forderung der \"Multilateralen Zusammenarbeit in Computational Neuroscience: Deutsch/and USA Israel Frankreich\" Vom 16. Juli 2015. [ online] Available at: https:/ /www.bmbf.de/foerderungen/bekanntmachung-1068.html [ Accessed 4 August 2017 ] . BMBF ( 2015b ). Bekanntmachung: Richtlinie zur Forderung von ''Altemativmethoden zum Tierversuch': Bundesanzeiger vom 24.12.2015. [ online] Available at: https:/ /www. bmbf.de/foerderungen/bekanntmachung.php?B=n24 [ Accessed 6 August 2017 ] . BMBF ( 2016). Lebenswissenschaftliche GrundlagenforschungALtemativenzum Tierver such. [ online] Available at: https:/ /www.bmbf.de/de/altemativen-zum-tierversuch -412.html [ Accessed 6 August 2017 ] . Buchmann Institute for Molecular Life Sciences (2017). BMLS Drug Delivery and 3R-models. [ online] Available at: https:/ /www.bmls.de/Drug_Delivery_and-3R Models/people.html [Accessed 6 August 2017 ] . Bundesministerium fiir Justiz und Verbraucherschutz ( 2017 ) . §46 TierSch Vers VEinzel norm. [ online] Available at: http://www.gesetze-im-intemet.de/tierschversv/_46. html [ Accessed 4 August 2017 ] . Bundesministerium fiir Wirtschaft und Energie (2017). Forderdatenbank Inhalts verzeichnis. [ online] Available at: http://www.foerderdatenbank.de/Foerder-DB/ Navigation/Foerderrecherche/inhaltsverzeichnis.html?get=ea6079646dcbaffo7 8c1252foafa99d6;views;document&doc=13310 [ Accessed 4 August 2017 ] . CAAT (n.d. a). CAAT History. [ online] Available at: http://caat.jhsph.edu/about/history .html [Accessed 26 July 2018 ] . CAAT ( n.d. b ) . About Us: Center for Alternatives to Animal Testing. [ online] Available at: http://caat.jhsph.edu/about/index.html [ Accessed 26 July 2018 ] . Chen, S., S.E. Palma-Vera, M. Langhammer, S.P. Galuska, B.C. Braun, E . Krause, A. Lucas-Hahn and J. Schoen (2017). An Air-liquid Interphase Approach for Model ing the Early Embryo-maternal Contact Zone. Scientific Reports, 7, 42298 [ online] Available at: https:/ /www.nature.com/articles/srep42298 [Accessed 12 February 2018 ] . Committee on Toxicity Testing and Assessment of Environmental Agents ( 2007 ). Tox icity Testing in the 21st Century: A Vision and a Strategy. [ online] Available at: http:// Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access HOW CAN THE FINAL GOAL OF COMPLETELY REPLACING ANIMAL 117 dels.nas.edu /resources/static-assets/ materials-based-on-reports/ reports-in-brief/ Toxicity_Testing_final.pdf [ Accessed 5 August 2017 ] . Cosmetics Europe ( 2017 ) . Promoting Science and Research. [ online] Available at: https:/ / www.cosmeticseurope.eu/how-we-take-action/promoting-science-research/ [ Ac cessed 4 August 2017 ] . Cronin, M. (2017). Non-animal Approaches The Way Forward. Report on a Euro pean Commission Scientific Conference. Brussels, Belgium. December 6-7, 2016. [ online] Available at: http:/ /ec.europa.eu/environment/chemicals/lab_animals/3r/ pdf/scientific_conference/non_animal_approaches_conference_report.pdf [ Accessed 26 July 2018] . Der Regierende Biirgermeister Senatskanzlei Berlin (2017). Senat beschliefit Entwurf des Charite-Vertrages 2018-2022. Pressemitteilung [ online] Available at: https:/ /www. berlin.de / rbmskzl/ aktuelles / pressemitteilungen/ 2017 / pressemitteilung.617676. php#search=0/022Tierversuch*0/022 [ Accessed 4 August 2017 ]. D FG ( 2017 ). Hochdurchsatzverfahren: D FG fordert modeme Forschungsinfrastrukturen in den Lebenswissenschaften. [ online] Available at: http:/ /www.dfg.de/service/ presse/pressemitteilungen/2017 /pressemitteilung_nr_28/index.html [ Accessed 6 August 2017] . Eddie, S.L., J.J. Kim, T.K. Woodruff and J.E. Burdette (2015). Microphysiological Mod eling of the Reproductive Tract: A Fertile Endeavor. Experimental Biology and Medicine, 239(9), pp. 1192-12O2. EPAA (2017). European Partnership for Alternative Approaches to Animal Testing Wachstum European Commission. [ online] Available at: https:/ /ec.europa.eu/ growth/sectors/chemicals/epaa_de [ Accessed 6 August 2017 ] . Epithelix ( 2017 ) . Toxicity of Inhaled Products: Acute, Long Term or Repeated Dose Test ing of Drugs/Formulations or Xenobiotics on Reconstructed Human Airway Tissues (MucilAirJ. [ online] Available at: http:/ /www.epithelix.com/services/toxicity-of inhaled-products [ Accessed 6 August 2017 ] . Esch, E.W., A. Babinski and D. Huh (2015). Organs-on-Chips at the Frontiers of Drug Discovery. Nature Reviews Drug Discovery 14, pp. 248-260. Ettel, A. ( 2018). Es wird nicht moglich sein, Tierversuche zu ersetzen. Welt. [ online] Avail able at: https:/ /www.welt.de/wirtschaft/article1734934oo/Tierversuche-Laengst nicht-alle-Tests-dienen-der-Forschung.html [Accessed 13 Feb. 2018] . EU-NETVAL (2018). EU-NETVAL (European Union Network of Laboratories for the Validation of Alternative Methods). [ online] Available at: https:/ /eurl-ecvamJrc. ec.europa.eu/eu-netval [ Accessed 12 February 2018] . EU-ToxRisk (2016). EU-ToxRisk An integrated European ''Flagship\" Pro gram Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century. [ online] Available at: http:/ /www.eu-toxrisk.eu/ [ Accessed 2 August 2017 ] . Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access 118 BAUMGARTL-SIMONS AND HOHENSEE EURL ECVAM (2017a). European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM). [ online] Available at: https:/ /eurl-ecvam.jrc.ec.europa.eu [ Accessed 4 August 2017] . EURL ECVAM (2017b). EURL ECVAM Recommendations. [online] Available at: https:/ /eurl-ecvam.jrc.ec.europa.eu/eurl-ecvam-recommendations [ Accessed 6 August 2017 ] . European Parliament (1986). Council Directive of 24 November 1986 on the Approxi mation of Laws, Regulations and Administrative Provisions of the Member States Regarding the Protection of Animals Used for Experimental and Other Scientific Purposes (86/609/EEC). Officialjoumal of the European Communities, L 358/1, p. 5. [ online] Available at: http:/ /eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri= CELEX:31986Lo609&from=EN [Accessed 5 March 2018] . European Parliament (2010 ). Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the Protection of Animals Used for Scientific Purposes. Officialjoumal of the European Communities, L 276, p. 33-79. [ online] Avail able at: http://eur-lex.europa.eu/legal-content/EN /TXT /?uri=CELEX:32010Loo63. [Accessed 3 August 2017 ] . FELASA ( n.d. ) . FELASA. [ online] Available at: http://www.felasa.eu/ [ Accessed 3 Au gust 2017 ] . Hartung, T. (2015). Food for Thought . . . The Human Whole Blood Pyrogen Test Lessons Learned in Twenty Years. ALTEX,32 (2), pp. 79-100. [ online] Available at: http:/ /altweb.jhsph.edu/altex/32_2/FFT.pdf [Accessed at 12 Feb. 2018] . Henneman, P., van P. Megchelen, M. Pijnappel, H. Smid, J. Wijnja and M. Zuidgeest (2015). In transitie! Nederland intemationaal toonaangevend in proefdiervrije innova ties. [ online] Available at: http://library.wur.nl/WebQuery/titel/2102149 [Accessed 26 July 2018] . HESPEROS (2017). Team. [ online] Available at: http:/ /www.hesperosinc.com/team/ [Accessed 10 January 2018] . Hildermann, L. (2015). Die EU-Tierversuchsrichtlinie und ihre Umsetzung in nation ales Recht: unionsund verfassungsrechtliche Aspekte. Dissertation. Universitat Trier. Hochschule fiir Technik und Wirtschaft Berlin, HTW-Berlin (2017). Bachelor-Life Sci ence Engineering. Official Website Hochschulefar Technik und Wirtschaft Berlin. [ on line] Available at: http://lse-bachelor.htw-berlin.de/studium/ [Accessed 6 August 2017 ] . Hoffmann, S., N. Mohle, M. Aufderheide, D. Steinritz, A. Tsoutsoulopoulos, A. Breit and 0. Krischenowski ( 2017 ). Validation of the CULT EX RFS Method to Assess the Acute Inhalation Toxicity of Dusts. [ online] Available at: https:/ /www.researchgate.net/ project/Validation-of-the-CULTEX-RFS-method-to-assess-the-acute-inhalation toxicity-of-dusts [Accessed 6 August 2017 ] . Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access HOW CAN THE FINAL GOAL OF COMPLETELY REPLACING ANIMAL 119 Hohensee, C. (2015). Fachgespriich zu Tierversuchsersatzverfahren im Deutschen Bund estag. [Blog] InVitro+Jobs. 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引用次数: 2
Abstract
2373. [ online] Available at: https:/ /www.mattek.com/reference-library/ identification-of-endocrine-disruptors-using-an-organotypic-vaginal-tissue model/ [Accessed 6 August 2017 ]. Ayehunie, S., Landry, T., Hayden, P. and Klausner M. ( 2016 ). Pre-validation of in vitro in vivo assays for vaginal irritation. In: Society of Toxicology 2016 Annual Meeting. [ online] Available at: https:/ /www.mattek.com/join-us-at-sot-2016/ [ Accessed 6 August 2017 ] . Baumgartl-Simons, C. (2017). Das Ende muss endlich wirksam verfolgt werden. Tierrechte, 02, p. 4. [ online] Available at: https:/ /www.tierrechte.de/images/stories/ Presse_und_Magazin_Tierrechte/Magazin_2-17 _.pdf [ Accessed nJanuary 2018] . BfR(2017a) .NationalerAusschussTierschutzgesetz-EJR. [ online ]Availableat:http:/ /www .bfr.bund.de/ de/nationaler_ausschuss_tierschutzgesetz.html [ Accessed 2 August 2017] . Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access 116 BAUMGARTL-SIMONS AND HOHENSEE BfR (2017b). Fragen und Antworten zum Deutschen Zentrum zum Schutz von Versuch stieren (B/3R). [ online] Available at: http://www.bfr.bund.de/cm/343/fragen-und antworten-zum-deutschen-zentrum-zum-schutz-von-versuchstieren-bf3r.pdf [ Accessed 4 August 2017 ] . BMBF (20n). Bekanntmachung des Bundesministeriums far Bi/dung und Forschung von Richtlinien zur Forderung ,,e:Bio lnnovationswettbewerb Systembiologie" Vom 17. Dezember 2010. [ online] Available at: https:/ /www.bmbf.de/foerderungen/ bekanntmachung.php?B=6o8 [ Accessed 4 August 2017 ] . BMBF (2015a). Bekanntmachung des Bundesministeriumsfar Bildung und Forschung von Richtlinien zur Forderung der "Multilateralen Zusammenarbeit in Computational Neuroscience: Deutsch/and USA Israel Frankreich" Vom 16. Juli 2015. [ online] Available at: https:/ /www.bmbf.de/foerderungen/bekanntmachung-1068.html [ Accessed 4 August 2017 ] . BMBF ( 2015b ). Bekanntmachung: Richtlinie zur Forderung von ''Altemativmethoden zum Tierversuch': Bundesanzeiger vom 24.12.2015. [ online] Available at: https:/ /www. bmbf.de/foerderungen/bekanntmachung.php?B=n24 [ Accessed 6 August 2017 ] . BMBF ( 2016). Lebenswissenschaftliche GrundlagenforschungALtemativenzum Tierver such. [ online] Available at: https:/ /www.bmbf.de/de/altemativen-zum-tierversuch -412.html [ Accessed 6 August 2017 ] . Buchmann Institute for Molecular Life Sciences (2017). BMLS Drug Delivery and 3R-models. [ online] Available at: https:/ /www.bmls.de/Drug_Delivery_and-3R Models/people.html [Accessed 6 August 2017 ] . Bundesministerium fiir Justiz und Verbraucherschutz ( 2017 ) . §46 TierSch Vers VEinzel norm. [ online] Available at: http://www.gesetze-im-intemet.de/tierschversv/_46. html [ Accessed 4 August 2017 ] . Bundesministerium fiir Wirtschaft und Energie (2017). Forderdatenbank Inhalts verzeichnis. [ online] Available at: http://www.foerderdatenbank.de/Foerder-DB/ Navigation/Foerderrecherche/inhaltsverzeichnis.html?get=ea6079646dcbaffo7 8c1252foafa99d6;views;document&doc=13310 [ Accessed 4 August 2017 ] . CAAT (n.d. a). CAAT History. [ online] Available at: http://caat.jhsph.edu/about/history .html [Accessed 26 July 2018 ] . CAAT ( n.d. b ) . About Us: Center for Alternatives to Animal Testing. [ online] Available at: http://caat.jhsph.edu/about/index.html [ Accessed 26 July 2018 ] . Chen, S., S.E. Palma-Vera, M. Langhammer, S.P. Galuska, B.C. Braun, E . Krause, A. Lucas-Hahn and J. Schoen (2017). An Air-liquid Interphase Approach for Model ing the Early Embryo-maternal Contact Zone. Scientific Reports, 7, 42298 [ online] Available at: https:/ /www.nature.com/articles/srep42298 [Accessed 12 February 2018 ] . Committee on Toxicity Testing and Assessment of Environmental Agents ( 2007 ). Tox icity Testing in the 21st Century: A Vision and a Strategy. [ online] Available at: http:// Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access HOW CAN THE FINAL GOAL OF COMPLETELY REPLACING ANIMAL 117 dels.nas.edu /resources/static-assets/ materials-based-on-reports/ reports-in-brief/ Toxicity_Testing_final.pdf [ Accessed 5 August 2017 ] . Cosmetics Europe ( 2017 ) . Promoting Science and Research. [ online] Available at: https:/ / www.cosmeticseurope.eu/how-we-take-action/promoting-science-research/ [ Ac cessed 4 August 2017 ] . Cronin, M. (2017). Non-animal Approaches The Way Forward. Report on a Euro pean Commission Scientific Conference. Brussels, Belgium. December 6-7, 2016. [ online] Available at: http:/ /ec.europa.eu/environment/chemicals/lab_animals/3r/ pdf/scientific_conference/non_animal_approaches_conference_report.pdf [ Accessed 26 July 2018] . Der Regierende Biirgermeister Senatskanzlei Berlin (2017). Senat beschliefit Entwurf des Charite-Vertrages 2018-2022. Pressemitteilung [ online] Available at: https:/ /www. berlin.de / rbmskzl/ aktuelles / pressemitteilungen/ 2017 / pressemitteilung.617676. php#search=0/022Tierversuch*0/022 [ Accessed 4 August 2017 ]. D FG ( 2017 ). Hochdurchsatzverfahren: D FG fordert modeme Forschungsinfrastrukturen in den Lebenswissenschaften. [ online] Available at: http:/ /www.dfg.de/service/ presse/pressemitteilungen/2017 /pressemitteilung_nr_28/index.html [ Accessed 6 August 2017] . Eddie, S.L., J.J. Kim, T.K. Woodruff and J.E. Burdette (2015). Microphysiological Mod eling of the Reproductive Tract: A Fertile Endeavor. Experimental Biology and Medicine, 239(9), pp. 1192-12O2. EPAA (2017). European Partnership for Alternative Approaches to Animal Testing Wachstum European Commission. [ online] Available at: https:/ /ec.europa.eu/ growth/sectors/chemicals/epaa_de [ Accessed 6 August 2017 ] . Epithelix ( 2017 ) . Toxicity of Inhaled Products: Acute, Long Term or Repeated Dose Test ing of Drugs/Formulations or Xenobiotics on Reconstructed Human Airway Tissues (MucilAirJ. [ online] Available at: http:/ /www.epithelix.com/services/toxicity-of inhaled-products [ Accessed 6 August 2017 ] . Esch, E.W., A. Babinski and D. Huh (2015). Organs-on-Chips at the Frontiers of Drug Discovery. Nature Reviews Drug Discovery 14, pp. 248-260. Ettel, A. ( 2018). Es wird nicht moglich sein, Tierversuche zu ersetzen. Welt. [ online] Avail able at: https:/ /www.welt.de/wirtschaft/article1734934oo/Tierversuche-Laengst nicht-alle-Tests-dienen-der-Forschung.html [Accessed 13 Feb. 2018] . EU-NETVAL (2018). EU-NETVAL (European Union Network of Laboratories for the Validation of Alternative Methods). [ online] Available at: https:/ /eurl-ecvamJrc. ec.europa.eu/eu-netval [ Accessed 12 February 2018] . EU-ToxRisk (2016). EU-ToxRisk An integrated European ''Flagship" Pro gram Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century. [ online] Available at: http:/ /www.eu-toxrisk.eu/ [ Accessed 2 August 2017 ] . Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access 118 BAUMGARTL-SIMONS AND HOHENSEE EURL ECVAM (2017a). European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM). [ online] Available at: https:/ /eurl-ecvam.jrc.ec.europa.eu [ Accessed 4 August 2017] . EURL ECVAM (2017b). EURL ECVAM Recommendations. [online] Available at: https:/ /eurl-ecvam.jrc.ec.europa.eu/eurl-ecvam-recommendations [ Accessed 6 August 2017 ] . European Parliament (1986). Council Directive of 24 November 1986 on the Approxi mation of Laws, Regulations and Administrative Provisions of the Member States Regarding the Protection of Animals Used for Experimental and Other Scientific Purposes (86/609/EEC). Officialjoumal of the European Communities, L 358/1, p. 5. [ online] Available at: http:/ /eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri= CELEX:31986Lo609&from=EN [Accessed 5 March 2018] . European Parliament (2010 ). Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the Protection of Animals Used for Scientific Purposes. Officialjoumal of the European Communities, L 276, p. 33-79. [ online] Avail able at: http://eur-lex.europa.eu/legal-content/EN /TXT /?uri=CELEX:32010Loo63. [Accessed 3 August 2017 ] . FELASA ( n.d. ) . FELASA. [ online] Available at: http://www.felasa.eu/ [ Accessed 3 Au gust 2017 ] . Hartung, T. (2015). Food for Thought . . . The Human Whole Blood Pyrogen Test Lessons Learned in Twenty Years. ALTEX,32 (2), pp. 79-100. [ online] Available at: http:/ /altweb.jhsph.edu/altex/32_2/FFT.pdf [Accessed at 12 Feb. 2018] . Henneman, P., van P. Megchelen, M. Pijnappel, H. Smid, J. Wijnja and M. Zuidgeest (2015). In transitie! Nederland intemationaal toonaangevend in proefdiervrije innova ties. [ online] Available at: http://library.wur.nl/WebQuery/titel/2102149 [Accessed 26 July 2018] . HESPEROS (2017). Team. [ online] Available at: http:/ /www.hesperosinc.com/team/ [Accessed 10 January 2018] . Hildermann, L. (2015). Die EU-Tierversuchsrichtlinie und ihre Umsetzung in nation ales Recht: unionsund verfassungsrechtliche Aspekte. Dissertation. Universitat Trier. Hochschule fiir Technik und Wirtschaft Berlin, HTW-Berlin (2017). Bachelor-Life Sci ence Engineering. Official Website Hochschulefar Technik und Wirtschaft Berlin. [ on line] Available at: http://lse-bachelor.htw-berlin.de/studium/ [Accessed 6 August 2017 ] . Hoffmann, S., N. Mohle, M. Aufderheide, D. Steinritz, A. Tsoutsoulopoulos, A. Breit and 0. Krischenowski ( 2017 ). Validation of the CULT EX RFS Method to Assess the Acute Inhalation Toxicity of Dusts. [ online] Available at: https:/ /www.researchgate.net/ project/Validation-of-the-CULTEX-RFS-method-to-assess-the-acute-inhalation toxicity-of-dusts [Accessed 6 August 2017 ] . Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access HOW CAN THE FINAL GOAL OF COMPLETELY REPLACING ANIMAL 119 Hohensee, C. (2015). Fachgespriich zu Tierversuchsersatzverfahren im Deutschen Bund estag. [Blog] InVitro+Jobs. Availab