The Relationship between Antipsychotic Medications and Cancer: A Review Article

Critical Comments in Biomedicine Pub Date : 2020-01-20 DOI:10.18502/CCB.V1I1.2871

Mohammad Javad Dehqan, S. Negintaji, Farnoosh Mirjalili, R. Bidaki, A. Mohammadi, A. Sahebnasagh, F. Saghafi

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Abstract

Background: Cancer is a global problem and causes lots of deaths across the world. Due to the high cost of manufacturing and developing new drugs, there is more willingness to use medications that may have anti-neoplastic effects. Objectives: Antipsychotic drugs have a long history of clinical use. Currently, there are several reports about the anticancer effects of antipsychotic drugs in different types of malignancies. Methods: In this study, the effects and mechanisms of several antipsychotic drugs on different types of cancer were investigated. The current investigations show that some antipsychotic drugs might inhibit the proliferation of cancer cells and some others can be used to ease the symptoms caused by cancer. Results: The anticancer effects of all antipsychotic drugs haven’t been thoroughly investigated and it is reported that few drugs may reverse the effects and increase the risk of neoplasm. Conclusions: Although some studies have revealed that antipsychotic drugs might beneficially affect cancer cells, high quality clinical trials are still needed to confirm these results.

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抗精神病药物与癌症的关系综述

背景:癌症是一个全球性问题，在世界范围内造成大量死亡。由于制造和开发新药的高成本，人们更愿意使用可能具有抗肿瘤作用的药物。目的:抗精神病药物具有悠久的临床应用历史。目前，关于抗精神病药物在不同类型恶性肿瘤中的抗癌作用已有几篇报道。方法:研究几种抗精神病药物对不同类型肿瘤的作用及其机制。目前的研究表明，一些抗精神病药物可能抑制癌细胞的增殖，而另一些抗精神病药物可以用来缓解癌症引起的症状。结果:所有抗精神病药物的抗肿瘤作用尚未得到充分的研究，有报道称少数药物可能逆转其作用并增加肿瘤发生的风险。结论:尽管一些研究表明抗精神病药物可能对癌细胞有益，但仍需要高质量的临床试验来证实这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Critical Comments in Biomedicine

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