M. Saravani, Mohsen Rokni, M. Mehrbani, Arian Amirkhosravi, Sanaz Faramarz, I. Fatemi, Mojdeh Esmaeili Tarzi, M. Nematollahi
{"title":"The evaluation of VEGF and HIF‐1α gene polymorphisms and multiple sclerosis susceptibility","authors":"M. Saravani, Mohsen Rokni, M. Mehrbani, Arian Amirkhosravi, Sanaz Faramarz, I. Fatemi, Mojdeh Esmaeili Tarzi, M. Nematollahi","doi":"10.1002/jgm.3132","DOIUrl":null,"url":null,"abstract":"Multiple sclerosis (MS) is an autoimmune disease that leads to myelin sheath destruction. Hypoxia‐inducible factor 1 (HIF‐1) has several roles in cells, such as inducing inflammation and angiogenesis. Recently, several lines of evidence have indicated the role of the hypoxia response and the HIF‐1 signaling pathway in an autoimmune disease such as MS. The present study aimed to evaluate the effects of HIF‐1α gene polymorphisms and vascular endothelial growth factor (VEGF) (as a major target gene of HIF‐1α) gene polymorphism on MS susceptibility.","PeriodicalId":328333,"journal":{"name":"The Journal of Gene Medicine","volume":"21 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"18","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Gene Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/jgm.3132","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 18
Abstract
Multiple sclerosis (MS) is an autoimmune disease that leads to myelin sheath destruction. Hypoxia‐inducible factor 1 (HIF‐1) has several roles in cells, such as inducing inflammation and angiogenesis. Recently, several lines of evidence have indicated the role of the hypoxia response and the HIF‐1 signaling pathway in an autoimmune disease such as MS. The present study aimed to evaluate the effects of HIF‐1α gene polymorphisms and vascular endothelial growth factor (VEGF) (as a major target gene of HIF‐1α) gene polymorphism on MS susceptibility.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
