Effects of enkephalins on arterial blood pressure are reduced by propranolol.

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI:10.1042/cs055237s

W Simon, K Schaz, U Ganten, G Stock, K H Schlör, D Ganten

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引用次数: 54

Abstract

1. The cardiovascular effects of enkephalins have been tested in normotensive Wistar-Kyoto rats. Methionine-enkephalin and leucine-enkephalin increased blood pressure and heart rate after infusion into the brain ventricles. 2. After intravenous injection, blood pressure was increased by methionine-enkephalin and leucine-enkephalin, but heart rate was increased by methionine-enkephalin only. 3. Propranolol treatment reduced the increases in blood pressure following intraventricular methionine-enkephalin and leucine-enkephalin, while only the methionine-enkephalin-induced increases in heart rate were reduced by propranolol. 4. Heart rate and blood pressure responses after intravenous administration of methionine-enkephalins and leucine-enkephalin were not affected by propranolol. 5. Since opioid peptides occur in the blood and in regions of the brain involved in blood pressure regulation, the demonstrated cardiovascular effects to intraventricular and intravenous enkephalins support a role of these peptides in central and peripheral mechanisms of blood pressure control.

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心得安可降低脑啡肽对动脉血压的影响。

1. 脑啡肽对心血管的影响已经在正常血压的Wistar-Kyoto大鼠身上进行了测试。蛋氨酸-脑啡肽和亮氨酸-脑啡肽注入脑室后血压和心率升高。2. 静脉注射后，蛋氨酸-脑啡肽和亮氨酸-脑啡肽使血压升高，而蛋氨酸-脑啡肽使心率升高。3.心得安可以降低脑内注射蛋氨酸-脑啡肽和亮氨酸-脑啡肽后血压的升高，而心得安只能降低蛋氨酸-脑啡肽引起的心率升高。4. 静脉注射蛋氨酸-脑啡肽和亮氨酸-脑啡肽后的心率和血压反应不受心得安的影响。5. 由于阿片肽存在于血液和大脑中参与血压调节的区域，已证实的对脑室内和静脉内脑啡肽的心血管作用支持了这些肽在血压控制的中枢和外周机制中的作用。

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Clinical science and molecular medicine. Supplement

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