Preparation and evaluation of anti-arthritic activity of Moringa oleifera leaves extract loaded silver nanoparticles

Abstract

Silver Nanoparticles (Ag-NPs) are increasingly used in various fields including medical, food, healthcare consumer and industrial purposes due to their unique physical and chemical properties. The conventional physical and chemical methods of synthesis of Ag-NPs seem to be very expensive and hazardous. Interestingly, biologically prepared Ag-NPs show high yield, solubility and high stability. The biologically Ag-NPs was characterized by UV-visible spectroscopy and SEM with EDAX. The appearance of specific absorbance peak at 440 nm indicates the presence of Ag-NPs. The development of Ag-NPs as anti-arthritic molecules is one of the most interesting approaches for arthritic treatment as it can overcome poor delivery and the problem of drug resistance. The anti-arthritic activity of developed MO-AgNPs was determined by albumin denaturation assay. MO-AgNPs (Moringa Olifera leaves extract loaded silver nanoparticles) exhibit 25% higher anti-arthritic activity when compared with standard Aspirin drug.