Clinicopathological profile of triple negative breast cancer in a tertiary health care centre of India

Abstract

Breast carcinoma is one of the most common malignancies affecting women in developing countries. It is divided into several subtypes, including triple negatives. TNBCs are found to have an aggressive behaviour and have a metastasic potential leading to an overall poorer prognosis.The aim was to study the clinicopathological profile of TNBC pateints including parameters like age, site, tumour size, histopathological type, histologic grade, lymphovascular invasion and nodal invasion and TNM Staging was done to study the overall prognosis.A four year retrospective study was conducted on ninety seven cases of breast carcinoma which were further classified based on immunohistochemical staining into four subtypes. The clinicopathological details and the histomorphological features of these patents were studied.Of the 208 cases, 97 cases were diagnosed as TNBC. The average age at presentation was 45 years. Most of the cases showed Nottingham Modification of Scarff Bloom-Richardson (NMBR) grade 3 (66%) and stage II (50.7%). Lymph node metastasis and Lymphovascular invasion was seen in 62% and 24.7% of cases. Infiltrating ductal carcinoma (not otherwise specified) type (94.8%) was the most common histological type. TNBC have an aggressive behaviour compared to other subtypes with higher SBR grade. Lymphovascular invasion and nodal metastasis.