La terapia insulinica nel diabete mellito di tipo 2

Il Diabete Pub Date : 2022-05-12 DOI:10.30682/ildia2201b
Anna Toffalini, Alessandro Mantovani, G. Zoppini
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Abstract

Type 2 diabetes is a very common metabolic disorder worldwide. The main defects of this disease are insulin resistance and a β cell dysfunction, leading to a reduction of insulin secretion over time. Insulin secretion is a complex mechanism that involves interactions among all the cells of the pancreatic insula. In addition, glucolipotoxicity may affect reversibly insulin secretion in type 2 diabetes. In recent years, several novel treatments have been becoming available for type 2 diabetes, nevertheless insulin still maintains an important role overall in specific situations including severe metabolic decompensation or pregnancy. The aim of the present narrative review is to discuss the main indications of insulin in the treatment of type 2 diabetes.
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2型糖尿病的胰岛素治疗
2型糖尿病是世界范围内非常常见的代谢紊乱。这种疾病的主要缺陷是胰岛素抵抗和β细胞功能障碍,随着时间的推移导致胰岛素分泌减少。胰岛素分泌是一个复杂的机制,涉及到胰岛所有细胞之间的相互作用。此外,糖脂毒性可能可逆地影响2型糖尿病患者的胰岛素分泌。近年来,已经出现了几种新的治疗2型糖尿病的方法,然而胰岛素在包括严重代谢失代偿或妊娠在内的特殊情况下仍然保持着重要的作用。本文的目的是讨论胰岛素治疗2型糖尿病的主要适应症。
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