The influx of tryptamine into snail (Helix pomatia) ganglia: comparison with 5-hydroxytryptamine.
IF 0.7 4区 生物学Q4 ZOOLOGYMalacologiaPub Date : 1979-01-01
H U Schröder, V Neuhoff, E Priggemeier, N N Osborne
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引用次数: 0
Abstract
Isolated ganglia possess the ability to concentrate tryptamine from an external medium by a process which is temperature sensitive and independent of sodium and other cations. Kinetic analysis of the accumulation process showed the influx of tryptamine to be a single mechanism with Km and Vmax values of 1.4 X 10(-4)M and 5 X 10(-8) mole/g/min. The influx of tryptamine is an unspecific process and is insensitive to a number of metabolic inhibitors and various analogues. The process of tryptamine influx is thus similar in principle to the low affinity uptake mechanism for 5-HT (see Osborne et al., 1975). The present data, which include some experiments on the release of 5-HT and tryptamine, are discussed from the point of view of a functional role for 5-HT and tryptamine in the snail CNS.
分离的神经节具有从外部介质中浓缩色胺的能力，该过程对温度敏感，不依赖于钠和其他阳离子。累积过程的动力学分析表明，色胺内流为单一机制，Km和Vmax分别为1.4 X 10(-4)M和5 X 10(-8) mol /g/min。色胺的内流是一个非特异性的过程，对许多代谢抑制剂和各种类似物不敏感。因此，色胺内流的过程在原则上与5-羟色胺的低亲和力摄取机制相似(见Osborne等人，1975)。从5-羟色胺和5-羟色胺在蜗牛中枢神经系统中的功能作用的角度讨论了目前的数据，包括一些关于5-羟色胺和色胺释放的实验。
期刊介绍：
Malacologia publishes papers on all groups of the Mollusca. Malacologia specializes in publishing long papers and monographic treatments. Complete data are especially appreciated. Papers must be of interest to an international readership. Papers in systematics, ecology, population ecology, genetics, molecular genetics, evolution and phylogenetic treatments are especially welcomed. Also welcomed are letters to the editor involving papers published or issues of import to science of the day.
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