Chemical and Biological Occupational Hazards in the Toxicology Laboratory

B. Ballantyne
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Abstract

In addition to the chemical, physical, flammability, thermal, electrical and radiation hazards common to laboratories in general, toxicology laboratories have specific occupational hazards that require their recognition, appreciation and development of management practices for protective and precautionary measures. These include exposure to test chemicals of poorly understood toxicology and to control chemicals of high biological potency. Additionally there may be exposure to allergenic materials such as latex or animal allergens, and to transmissible animal diseases. This chapter reviews the routes and natures of hazardous exposures in the toxicology laboratory, specific allergenic and infective problem areas, and necessary protective and precautionary measures. Keywords: animal allergens; latex; sensitization; zoonoses; protection; precautionary measures; atopy; respiratory function tests; skin-prick tests; solvents; carcinogens; laboratory safety
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毒理学实验室的化学和生物职业危害
除了实验室普遍存在的化学、物理、可燃性、热、电和辐射危害外,毒理学实验室还有特殊的职业危害,需要它们认识、了解和制定保护和预防措施的管理做法。这些措施包括接触对毒理学知之甚少的试验化学品,以及控制具有高生物效力的化学品。此外,还可能暴露于致敏物质,如乳胶或动物过敏原,以及可传播的动物疾病。本章回顾了毒理学实验室中危险暴露的途径和性质,特定的过敏原和感染问题区域,以及必要的保护和预防措施。关键词:动物过敏原;乳胶;敏化;人畜共患病;保护;预防措施;异位性;呼吸功能检查;皮测试;溶剂;致癌物质;实验室安全
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