Electrically isolated buried electrode biosensor for detecting folic acid concentration

Alivia Basak, S. Chakraborty, Chirantan Das, A. Mukherjee, R. Saha, A. Karmakar, S. Chattopadhyay
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Abstract

The current study sought to detect and quantify different folic acid concentrations in Phosphate Buffer Saline (PBS) by employing Electrical Impedance Spectroscopy (EIS).This technique provides a simple, rapid, precise and cost-effective platform for folic acid monitoring. An on-wafer platform has been developed to perform the necessary electrical measurements. Variation of electrical parameters such as impedance, capacitance and conductance for six different concentrations ranging from 4 mg/dl to 6 mg/dl are analyzed. The capacitance and conductance are observed to increase whereas impedance has been found to decrease with increasing folic acid content in saline. FT-MIR spectrum shows distinct confirmatory peaks relevant to the folic acid constituents in the IR range 4000 cm-1 to 400 cm-1.
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用于检测叶酸浓度的电隔离埋极生物传感器
本研究旨在利用电阻抗谱(EIS)检测和定量磷酸缓冲盐水(PBS)中不同的叶酸浓度。该技术为叶酸监测提供了一个简单、快速、精确、经济的平台。晶圆上平台已被开发用于执行必要的电气测量。分析了6种浓度范围为4mg /dl至6mg /dl的溶液中阻抗、电容和电导等电学参数的变化。随着盐中叶酸含量的增加,电容量和电导增加,而阻抗降低。FT-MIR光谱在4000 cm-1 ~ 400 cm-1红外范围内显示与叶酸成分相关的不同验证峰。
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