Akurasi Spesivisitas dan Sensitivitas Angka RMI 2 Skor pada Penderita Tumor Ganas Ovarium di RSUP Dr. Hasan Sadikin Bandung Periode 2017−2018

Abstract

Tujuan : Penelitian ini bertujuan untuk mengetahui spesifitas dan sensitivitas skor RMI 2 dalam  menentukan  keganasan ovarium. Kadar CA 125 dan skor RMI 2 diukur dari hasil pemeriksaan histopatologi digunakan sebagai pemeriksaan gold standard. Penelitian ini dilakukan pada periode Januari 2017−Desember 2018. Metode : Penelitian ini menggunakan metode observasional analitik dengan rancangan cross sectional. Data kategorik diuji dengan uji chi-square atau  uji Exact Fisher. Data numerik digunakan  uji-t tidak berpasangan atau  uji Mann Whitney. Sumber data diperoleh dari rekam medis pasien di Poli Ginekologi Onkologi RSUP Dr. Hasan Sadikin Bandung berdasarkan angka skor RMI 2 pada penderita suspek tumor ganas ovarium. Hasil : Sampel berjumlah 172 dengan  31 berkategori  jinak  dan 141 berkategori ganas berdasarkan hasil histopatologi. Hasil penelitian  menunjukkan  nilai median CA 125 kelompok ganas dibanding kelompok jinak (437, 05 vs 212,14) bermakna secara statistik p = 0,001 (nilai p 200 dengan sensitivitas 95,74% dan spesifisitas 16,12%. Kesimpulan : Skor  RMI 2 adalah metode yang digunakan untuk memprediksi tumor ganas ovarium. Hal ini sangat berguna digunakan dengan  kombinasi CA 125 dengan hasil pemeriksaan ultrasonografi (USG) dan status menopause atau dikenal dengan Risk Malignancy Index (RMI skor 2 cut off point >200 ) dengan sensitivitas 95,74%, spesifisitas 16,12%dan akurasi 81,39 %. Skor RMI 2 mempunyai sensitivitas yang tinggi, tetapi mempunyai spesivisitas yang rendah, sehingga membutuhkan penelitian lebih lanjut. Accuracy of Specificity and Sensitivity of RMI 2 Score Numbers in Ovarium Fanner Tumors in RSUP Dr. Hasan Sadikin Bandung Period 2017-2018 Abstract Objective : This study aims to determine the specificity and sensitivity of RMI 2 score in ovarian malignancy. The CA 125 level and the RMI 2 score were measured and adjusted by histopathology examination as gold standard. This research was conducted in period January 2017−December 2018. Methods : This research used observational analitic research method with cross sectional design. Categorical data were tested by chi-square test or Fisher's Exact test. Numerical data are used unpaired t-test or Mann Whitney test. The source of data from medical records of patients in Gynecology Oncology Clinic Dr. Hasan Sadikin Bandung based on the RMI 2 score with suspected ovarian malignant tumors. Result : Samples were 172 with 31 benign categories and 141 malignant categories based on the results of histopathology. The results showed a median value of CA 125 of the malignant group compared to the benign group (437, 05 vs. 212.14) statistically significant p = 0.001 (p value 200 with a sensitivity of 95.74% and specificity of 16.12%. Conclusion : This study is an RMI 2 score is a useful way as a predictor of ovarian malignancy. This is very useful to use with a combination of CA 125 with the results of ultrasonography (USG) and menopausal status or known as the Risk Malignancy Index (RMI score 2 cut off point> 200) with a sensitivity of 95.74%, specificity 16.12% and accuracy 81 , 39%. RMI 2 score has high sensitivity, but has low specificity, so it needs further research. Key words : CA 125, RMI 2 score, ovarian malignancy