{"title":"Next-generation head-mounted microscopes for large-scale neural recordings","authors":"J. Scherrer, G. F. Lynch, Jie J. Zhang, M. Fee","doi":"10.1364/brain.2023.bm3b.2","DOIUrl":null,"url":null,"abstract":"We present a fluorescence microscope design that enables imaging of thousands of cortical neurons in freely-moving mice. The design eliminates traditional illumination optics, allowing for head-mounted microscopes with both a lower weight (1.4 gram) and a larger field-of-view (~4 mm diameter) than previously possible.","PeriodicalId":111173,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)","volume":"10 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1364/brain.2023.bm3b.2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
We present a fluorescence microscope design that enables imaging of thousands of cortical neurons in freely-moving mice. The design eliminates traditional illumination optics, allowing for head-mounted microscopes with both a lower weight (1.4 gram) and a larger field-of-view (~4 mm diameter) than previously possible.