{"title":"Putative Receptors for Bacillus Thuringiensis Var. Israelensis Cry11Aa in Haemonchus Contortus Larvae","authors":"F. L. Leivas Leite","doi":"10.54026/aroic/1002","DOIUrl":null,"url":null,"abstract":"Objectives: Through bioinformatics analysis, predict Haemonchus contortus larvae putative receptors for Cry11Aa. Results: Using a PyDOCK predicted high affinity interaction, as demonstrated by the highly negative binding energies of -57.2, -72.8, and -68.4 respectively for HC23, H-GAL-GP, H11, and all receptors docked to the domain II of Cry11Aa. Conclusion: These results suggest that Bti Cry11Aa toxin may use the proteins HC23, H-GAL-GP, and H11 as a receptor in Haemonchus contortus larvae and by doing so, carry out its nematicidal effect.","PeriodicalId":193352,"journal":{"name":"Advance Research in Organic and Inorganic Chemistry (AROIC)","volume":"113 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advance Research in Organic and Inorganic Chemistry (AROIC)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54026/aroic/1002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: Through bioinformatics analysis, predict Haemonchus contortus larvae putative receptors for Cry11Aa. Results: Using a PyDOCK predicted high affinity interaction, as demonstrated by the highly negative binding energies of -57.2, -72.8, and -68.4 respectively for HC23, H-GAL-GP, H11, and all receptors docked to the domain II of Cry11Aa. Conclusion: These results suggest that Bti Cry11Aa toxin may use the proteins HC23, H-GAL-GP, and H11 as a receptor in Haemonchus contortus larvae and by doing so, carry out its nematicidal effect.
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