Y. Ogra, Shunji Nagasaki, A. Yawata, Yasumi Anan, Koichi Hamada, A. Mizutani
{"title":"Metallomics approach to changes in element concentration during differentiation from fibroblasts into adipocytes by element array analysis.","authors":"Y. Ogra, Shunji Nagasaki, A. Yawata, Yasumi Anan, Koichi Hamada, A. Mizutani","doi":"10.2131/jts.41.241","DOIUrl":null,"url":null,"abstract":"We aimed to establish an element array analysis that involves the simultaneous detection of all elements in cells and the display of changes in element concentration before and after a cellular event. In this study, we demonstrated changes in element concentration during the differentiation of 3T3-L1 mouse fibroblasts into adipocytes. This metallomics approach yielded unique information of cellular response to physiological and toxicological events.","PeriodicalId":231048,"journal":{"name":"The Journal of toxicological sciences","volume":"38 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of toxicological sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2131/jts.41.241","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
We aimed to establish an element array analysis that involves the simultaneous detection of all elements in cells and the display of changes in element concentration before and after a cellular event. In this study, we demonstrated changes in element concentration during the differentiation of 3T3-L1 mouse fibroblasts into adipocytes. This metallomics approach yielded unique information of cellular response to physiological and toxicological events.
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