{"title":"Analysis of Cytokines in Sera from Type 1 Diabetic Patients at Diagnosis","authors":"I. Yoon, C. Shin, S. Yang","doi":"10.6065/JKSPE.2011.16.1.13","DOIUrl":null,"url":null,"abstract":"Results: Patients showed significantly higher levels of IL-1β (P ˂ 0.01), IL-10 (P ˂ 0.01), and TNF-α (P =0 .019), than the healthy controls. In 12 of 35 patients, the insulin autoantibody (IAA) was positive (34%) and the level of IAA was correlated with IL-10 (r = 0.454, P = 0.006), and TNF-α (r = 0.368, P = 0.030). Conclusion: These results suggest that IL-1β, TNF-α, and IL-10 play a role in the pathogenesis of T1DM, and the level of the IAA is correlated with IL-10 and TNF-α. (J Korean Soc Pediatr Endocrinol 2011;16:13-19)","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"85 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Korean Society of Pediatric Endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6065/JKSPE.2011.16.1.13","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Results: Patients showed significantly higher levels of IL-1β (P ˂ 0.01), IL-10 (P ˂ 0.01), and TNF-α (P =0 .019), than the healthy controls. In 12 of 35 patients, the insulin autoantibody (IAA) was positive (34%) and the level of IAA was correlated with IL-10 (r = 0.454, P = 0.006), and TNF-α (r = 0.368, P = 0.030). Conclusion: These results suggest that IL-1β, TNF-α, and IL-10 play a role in the pathogenesis of T1DM, and the level of the IAA is correlated with IL-10 and TNF-α. (J Korean Soc Pediatr Endocrinol 2011;16:13-19)
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