Large-area bio-electronic sensors for early detection of pancreatic-biliary cancer protein markers

Abstract

Pancreatic-biliary cancer represents a challenge for clinicians since the detection is performed at later stages and treated with palliative approaches. A screening method for the early detection should be of paramount importance. The aim of this study is the detection of pancreatic mucinous cysts protein markers (MUC1) in human serum down to the physical limit, using an Electrolyte-gated FET based technology, namely the "Single-Molecule assay with a large Transistor" (SiMoT) platform. The structure and transistor components have been developed on plastic substrates. The 3D gate structure is compatible with an ELISA plate. The functionalization procedure is assessed independently through Surface Plasmon Resonance, enabling the real-time monitoring of the gold modification with antibodies essential for the assay.