Systematized review of the literature on postoperative nausea and vomiting

Abstract

Introduction: Postoperative nausea and vomiting (PONV) is the most common adverse effect, after postoperative pain, with an incidence of 31.1% to 80%, which increases pain, favors broncho aspiration, wound dehiscence, and hematoma formation. Methodology: Systematized search keywords, postoperative nausea and vomiting, Incidence, therapeutics, Apfel score and risk score for postoperative nausea and vomiting, in PubMed database, the Cochrane central register of controlled trials and in http://www.clinicaltrials.gov. Results: A total of 2750 articles were obtained, and 62 articles were chosen for inclusion. Discussion: The drugs used as monotherapy to mitigate PONV such as palonosetron, fosaprepitant and aprepitant, show better results than the rest of the drugs. Conclusion: Currently, NK1 receptor antagonist drugs and 5-HT3 antagonists have been shown to have the best results in preventing PONV, however, the management of PONV should be multimodal and individualized.