The Component Analysis of Propofol and Etomidate Mixture and Its Clinical Efficacy

2015 Seventh International Conference on Measuring Technology and Mechatronics Automation Pub Date : 2015-06-13 DOI:10.1109/ICMTMA.2015.280

Yong Liao, Yan You, Xuejun Zhou, Yang Guo, Zhi-Ling Tang, Q. Wang, Daolin Jian

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Abstract

At present, medication safety is the key event in hospital. This paper discusses the pharmacy stability of propofol and etomidate mixture and its clinical efficacy in combination. In order to solve the problem efficiently, we adopt a high performance liquid chromatography(HPLC)and a nuclear magnetic resonance spectroscopy(NMR) to determinate the stability of propofol and etomidate mixture fristly. Then 120 patients of early pregnancy undergoing abortion surgeries were randomly assigned to propofol group(P group), etomidate group(E group) and propofol + etomidate group(EP group). Patients in P group were induced with 1% propofol 15ml. In E group, Patients were induced with 0.2% etomidate 15ml. In EP group, induction was performed with 1% propofol 10ml and 0.2% etomidate 5ml. To compare the results of hemodynamics, injection pain, myoclonus and recovery time among groups. As a results, the comparision of HPLC and H1-NMR showed nice chemical stability of samples. EP group has obvious advantages.

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异丙酚与依托咪酯合剂的成分分析及临床疗效

当前，医院的用药安全是重中之重。本文探讨异丙酚与依托咪酯合剂的药学稳定性及其联用的临床疗效。为了有效地解决这一问题，我们首先采用高效液相色谱法(HPLC)和核磁共振波谱法(NMR)测定异丙酚和依托咪酯混合物的稳定性。将120例进行人工流产手术的早孕患者随机分为异丙酚组(P组)、依托咪酯组(E组)和异丙酚+依托咪酯组(EP组)。P组采用1%异丙酚15ml诱导。E组患者给予0.2%依托咪酯15ml诱导。EP组以1%异丙酚10ml、0.2%依托咪酯5ml诱导。比较两组患者血流动力学、注射痛、肌阵挛及恢复时间。结果表明，HPLC和H1-NMR的对比表明样品具有良好的化学稳定性。EP组优势明显。

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2015 Seventh International Conference on Measuring Technology and Mechatronics Automation

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