Evaluation of IL-8 and IL-10 Levels in men with Irritable Bowel Syndrome

Abstract

Irritable Bowel Syndrome (IBS) is a common disorder of the large intestine. This study was designed to Estimation of interleukin 8 and 10 in human suffering from irritable bowel syndrome and the relationship with age and period of disease. A total of 88 men participated in this study, including 57 men as patient, and 31 as healthy, who were collected from Al-Fayhaa Hospital in Basrah. The patients was classified according to age into (30-40), (41-50) and (51-60), and according to the disease period into (1-5) and (6-10) years. The healthy were aged (30-60 years).IL-8 and IL-10 were measured using ELISA technique and The data statistical analysis software (One-way Anova) and Mann-Watny test. The results showed a significant increase of interleukin-8 (IL-8) for patients at P≤0.001, while there was a significant decrease in the level of interleukin-10 (IL-10) at P≤0.001. Regarding the age groups, the results did not show variation of IL-8 levels .while, the level of IL-10 in the (41-50 years) was significantly lower. As for the relationship between the duration of the disease there is no significant differences. The study concluded that inflammations play a role in inducing irritable bowel syndrome and the age group (41-50) was more affected.