Bacterial protein secretion and targeting

Abstract

Introduction Historical Outline Protein Targeting to the Translocase Signal Peptides Co-translational Protein Targeting Post-translational Protein Targeting Converging Targeting Pathways Translocase: A Multisubunit Integral Membrane Protein Complex SecA SecY SecE SecG SecD, SecF, and YajC Conserved Protein Translocases in Bacteria, Eukaryotes, and Archaea Role of Lipids in Protein Translocation Mechanism of Protein Translocation ATP-driven Translocation Proton Motive Force-driven Translocation Dynamics of the Protein-conducting Channel Regulation of Protein Translocation Outlook and Perspectives Acknowledgments Keywords: translocation; membranes; SecA; SecY; SecE; SecB; SecD; SecF; SRP