{"title":"Fluorescence Photobleaching Recovery Measurements of Facilitated Diffusion","authors":"E. Pike, H. J. Gould, F. Watanabe","doi":"10.1364/pcta.1988.pcs159","DOIUrl":null,"url":null,"abstract":"The feasibility of a direct measurement of sliding of proteins along a DNA chain by the fluorescence photobleaching recovery technique is demonstrated. The results obtained with a protein, histone H1, provides a firm basis for the understanding of the \"facilitated diffusion\" mechanism by which site-specific DNA binding proteins are thought to find efficiently their unique loci.","PeriodicalId":371566,"journal":{"name":"Photon Correlation Techniques and Applications","volume":"25 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photon Correlation Techniques and Applications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1364/pcta.1988.pcs159","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The feasibility of a direct measurement of sliding of proteins along a DNA chain by the fluorescence photobleaching recovery technique is demonstrated. The results obtained with a protein, histone H1, provides a firm basis for the understanding of the "facilitated diffusion" mechanism by which site-specific DNA binding proteins are thought to find efficiently their unique loci.
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