The Effect of Concentration Calcium Alginate On Metformine Encapsulated

Abstract

— This research aimed to study the effect of concentration calcium alginate on metformine encapsulation processes and investigated characteristic of metformine encapsulation. The encapsulation of metformine performed using chitosan and calcium alginate polymers with calcium chloride as crosslink agent. The concentrations of calcium alginate were varieties 0.5%; 1.0%; 1.5%; 2.0%; 2.5%; and 3.0% (w/v). The results showed that the highest encapsulation efficiency of metformine on concentration of alginate 2.0% (w/v) and the lowest in the alginate 0% (w/v), respectively by 80.51% and 55.94%. Encapsulation resulted with the highest the spectra FTIR analysis showed that there is vibration in 1497.91 cm -1 that indicated interaction between the carboxyl functional group of alginate and the amine functional group of chitosan