Inhibitory activity of organic solvent extracts of Murraya koenigii on Staphylococcus aureus

Abstract

Staphylococcus aureus is one of the most in famous and widespread bacterial pathogen. This pathogen can cause a wide variety of diseases, ranging from moderately severe skin infections to fatal pneumonia and sepsis. Treatment of Staph. aureus infections is complicated due to antibiotic resistance. There has been ongoing and increasing interest in the extraordinarily high number of toxins and other virulence determinants that Staph. aureus produces and how they impact disease. In the past few decades, a more dangerous form of Staph.aureus has emerged. This form is known as Methicillin-Resistant Staph.aureus and usually referred to by the acronym MRSA. Keeping in view of the problem of Antimicrobial Resistance(AMR).This study was designed to explore antibacterial activity of a common kitchen herb Murraya koengii against pathogenic gram positive Staphylococcus aureus.Four different plant extracts were prepared using solvents- Methanol, Hexane, Aqueous and Ethanol+Aqueous (1:1) and tested against Staphylococcus aureus by using Kirby bauer Disc diffusion method. Methicillin antibiotic disc was used as the positive control.