Expanding The Spectrum Of Biomarkers For Heart Disease: Homocysteine, Us Crp And Lipoprotein(A)

Tania Leme da Rocha Martinez
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Abstract

Taking into consideration that frequently cardiovascular patients do not present major risk factors, there remains a residual risk that can be, at least in part, measured by biomarkers of thrombosis and inflammation, based on clinical trials and clinical observations. This paper presents the role of three biomarkers - Homocysteyne, ultra sensitive C-Reactive Protein and Lipoprotein(a). The official Cardiac and Atherosclerosis Medical Societies conducts expert meetings that publish Recommendations for each of them. These Recommendations may help and guide clinicians as to their decision making regarding prevention of atherosclerotic cardiovascular diseases. Regarding hyperhomocysteinemia a healthy diet is the first choice, before prescribing folic acid and B vitamins supplements. A physician taking any type of nutritional approach to reducing risk should consider a person's overall risk factor profile and personalized diet. As for the inflammatory marker ultra sensitive C-Reactive Protein there is a strong association with risk of fatal vascular events than non fatal vascular events.
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扩大心脏疾病生物标志物的范围:同型半胱氨酸、Us Crp和脂蛋白(A)
考虑到心血管患者通常不存在主要危险因素,根据临床试验和临床观察,仍然存在剩余风险,至少部分可以通过血栓和炎症的生物标志物来测量。本文介绍了三种生物标志物-同型半胱氨酸,超敏感c反应蛋白和脂蛋白(a)的作用。官方的心脏和动脉粥样硬化医学协会召开专家会议,发布针对每种疾病的建议。这些建议可以帮助和指导临床医生在预防动脉粥样硬化性心血管疾病方面的决策。对于高同型半胱氨酸血症,在服用叶酸和B族维生素补充剂之前,健康饮食是第一选择。医生采取任何类型的营养方法来降低风险应该考虑一个人的整体风险因素概况和个性化的饮食。至于炎症标志物超敏感c反应蛋白,与致死性血管事件的风险相比,与非致死性血管事件的风险有很强的相关性。
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