Evaluation of anti-inflammatory effects of Pergularia Daemia latex using experimental animal models

Abstract

Pergularia daemia (Apocynaceae) plays an important role in traditional ayurvedic and siddha for the treatment of asthma, bronchitis, and jaundice. Interestingly, the latex of (PDL) is applied to cure Pergularia daemia headache, migraine, boils, wounds and scabies. The present study is aimed to evaluate the anti-inflammatory efficacy of PDL in animal. Orally, pre-treated three different doses (100, 200 mg/kg) of PDL in order to evaluate distinct phases of anti-inflammatory effects. The inhibition ratio of the PDL (200 mg/kg, (P < 0.01)) on carrageenan, Phorbol 12-myristate 13-acetate (PMA) in rats were 66.46 and 54.04% respectively better than the inhibition ratio of indomethacin (5 mg/kg) were 52.31% and 70.33% respectively in the two model. PDL sustains exemplary anti-inflammatory activity.