Infertilidade masculina decorrente de microdeleções no cromossomo Y

Abstract

Objective

Address male infertility caused by microdeletions on Y chromosome and present possible treatment through assisted human reproduction techniques.

Methods

Survey data from the scientific literature in the field of reproductive medicine.

Results

When compared with other causes of infertility, the microdeletions on Y chromosome are the relatively frequent. The Y chromosome is essential for male sex determination and there are in his long arm regions responsible for spermatogenesi, it's they AZFa, AZFb and AZFc. Such regions may be deleted causing male infertility by contain multiple genes essential for spermatogenesis. Thanks to advances in medicine, now several cases of infertility are treatable through assisted reproduction techniques. Among the techniques, the MSOME stands out as a methodology that selects only morphologically normal sperm to be used in insemination increasing the chances of pregnancy.

Conclusions

Male infertility has increased considerably in recent years and the genetic causes are one of the major consequences of this. Y chromosome microdeletions can cause mild oligozoospermia or azoospermia depending on the AZF region affected. For lighter causes, the couple may use some assisted reproductive techniques and to the most serious causes the solution to the couple is using donated gametes.