Association of Chlamydia trachomatis, Mycoplasma spp., Ureaplasma urealyticum and U. parvum with Human Papillomavirus in Patients with Cervical Cancer

A. Sahara, F. Ibrahim, M. Massi, A. Yasmon
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引用次数: 1

Abstract

Besides human papillomavirus (HPV), the cervical carcinogenesis is also affected by many risk factors including pathogenic bacteria such as Chlamydia trachomatis (CT), Mycoplasma spp. (MS), Ureaplasma urealyticum (UU), and U. parvum (UP) infections. Thus, we studied the bacterial infections for 68 patients with cervical cancerous cases and other cervical problems. Cervical swab samples were collected by specialist doctors and tested for the pathogenic bacteria by real time polymerase chain reaction (rPCR) and HPV by conventional PCR. Of 68 patients, 22 were diagnosed as cervical cancer and 46 were diagnosed as other cervical problems. All patients with cervical cancer were HPV positive, while the patients with other cervical problems were HPV negative. Of 22 HPV positive-cervical cancer patients, 7 (31.82%), 6 (27.27%), 3 (13.64%) were positive for MS, UU, and UP, respectively. None of the patients was CT positive. For 46 HPV negative-other cervical problem patients, 6 (13.04%), 12 (26.09%), 20 (43.48%), and 22 (47.83%) were positive for CT, MS, UU, and UP, respectively. There was no association of CT, MS, and UU infections with the HPV positive-cervical cancer patients (p >0.05). However, there is a negative correlation between UP infection and the HPV negative-other cervical problem patients (p<0.05).
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宫颈癌患者沙眼衣原体、支原体、解脲支原体和细小支原体与人乳头瘤病毒的关系
除了人乳头瘤病毒(HPV)外,宫颈癌的发生还受到许多危险因素的影响,包括致病菌,如沙眼衣原体(CT)、支原体(MS)、解脲支原体(UU)和细小脲原体(UP)感染。因此,我们对68例宫颈癌及其他宫颈疾病患者的细菌感染进行了研究。专科医生采集宫颈拭子样本,采用实时聚合酶链反应(real - time polymerase chain reaction, rPCR)检测致病菌,采用常规PCR检测HPV。在68名病人中,22名被诊断为子宫颈癌,46名被诊断为其他子宫颈问题。所有宫颈癌患者均为HPV阳性,而其他宫颈问题患者均为HPV阴性。22例HPV阳性宫颈癌患者中,MS阳性7例(31.82%),UU阳性6例(27.27%),UP阳性3例(13.64%)。所有患者均为CT阳性。46例HPV阴性-其他宫颈问题患者中,CT、MS、UU、UP分别阳性6例(13.04%)、12例(26.09%)、20例(43.48%)、22例(47.83%)。CT、MS、UU感染与HPV阳性宫颈癌患者无相关性(p >0.05)。而UP感染与HPV阴性-其他宫颈问题患者呈负相关(p<0.05)。
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