Histopathological Review and Distribution of Granulomatous Inflammatory Disorders in Makurdi, North Central Nigeria

Abstract

Granulomatous inflammation is a pattern of chronic inflammation characterized by the presence of granulomas consisting of microscopic aggregates of macrophages transformed into epithelioid cells surrounding by a collar of lymphocytes and occasioned plasma cells. The study aimed to determine the distribution by tissue site, histological patterns of granulomatous inflammatory disorders in Benue State University Teaching Hospital (BSUTH), Makurdi over a 5-year period. This was a 5 year (March 2013 – February 2018) retrospective study of all cases diagnosed as granulomatous inflammatory disorders on Haematoxylin and Eosin-stained sections at the Anatomical pathology Department. Ziehl-Neelsen special stain was also done on all specimens. A total of two hundred and thirty-six (236) cases of granulomatous inflammatory disorders were diagnosed, analysed and categorized based on the tissue site, on Haematoxylin and Eosin-stained sections; Ziehl-Neelsen special stain was done on all cases. The most common sites were cervical lymph nodes, appendix, skin, testicular tissues etc with the Eyelid been the least common site.