Research on the Construction and Functional Connection of Resting-State Brain Networks in Patients with Schizophrenia

Xuhui Chen, Jingjing Jiao, Ming Ke
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Abstract

In the resting state, the fMRI data were collected and preprocessed in patients with schizophrenia. Used the correlation analysis of seed and T-test method, the brain functional networks were constructed based on the complex network theory, and the statistical properties of the networks were analyzed. The result showed that the brain functional network had significant small-world properties in patients with schizophrenia. The study also indicated that the model of complex network is a very useful tool and new perspective for analysing the brain functional network in the overall perspective. The finding makes a better understanding of the neurophysiological mechanism of schizophrenia.
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精神分裂症患者静息状态脑网络的构建及功能联系研究
在静息状态下,收集精神分裂症患者的fMRI数据并进行预处理。采用种子相关分析和t检验方法,基于复杂网络理论构建了脑功能网络,并对网络的统计特性进行了分析。结果表明,精神分裂症患者的脑功能网络具有明显的小世界特性。研究还表明,复杂网络模型是从整体角度分析脑功能网络的一个非常有用的工具和新的视角。这一发现有助于更好地理解精神分裂症的神经生理机制。
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