A Brief Notes on Gene Therapy, Cell Therapy and Cell-Based Gene Therapy for Alzheimer’s Disease

A. Chakraborty, Anil Diwan
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Abstract

Alzheimer’s disease (AD) is known as an age-related neurodegenerative disease where progressive loss of memory associated with cognition defects has been noticed. Molecular analysis of AD revealed the formation of aggregated amyloid-β protein and hyper phosphorylated tau tangles at the synaptic circuit, which causes the loss of neuronal communication.
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阿尔茨海默病的基因治疗、细胞治疗和基于细胞的基因治疗综述
阿尔茨海默病(AD)是一种与年龄相关的神经退行性疾病,人们已经注意到与认知缺陷相关的记忆力进行性丧失。AD的分子分析揭示了突触回路中聚集的淀粉样蛋白-β蛋白和过度磷酸化的tau缠结的形成,导致神经元通讯丧失。
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