Ammar Yahya Kadhim Almamoori, G. H. A. Elsamie, M. Metwally, Samir Ali
{"title":"Sono and photo stimulated Chlorine E6 nanocomposite in tumor-bearing mice: upcoming cancer treatment","authors":"Ammar Yahya Kadhim Almamoori, G. H. A. Elsamie, M. Metwally, Samir Ali","doi":"10.31487/J.RDI.2019.03.04","DOIUrl":null,"url":null,"abstract":"This study was directed at study the effectiveness of cancer targeted therapy using the activated Chlorine E6 nanocomposite (Nano-CE6). Study was applied on male Swiss albino mice, implanted with Ehrlich tumor (EAC) divided into six groups. Two energy sources were used; laser and Ultrasound. Results showed that Nano-CE6 is a potential sensitizer for photodynamic or sonodynamic treatment of tumor. Nano-CE6 plays an important role in tumor growth inhibition and cell death induction. Activated Nano-CE6 with both infrared laser and ultrasound has a potential antitumor effect. The results indicated that (FA–NGO–CE6) could be used as a unique nanocomposite for cancer targeted therapy SPDT.","PeriodicalId":308916,"journal":{"name":"Radiology and Medical Diagnostic Imaging","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiology and Medical Diagnostic Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31487/J.RDI.2019.03.04","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
This study was directed at study the effectiveness of cancer targeted therapy using the activated Chlorine E6 nanocomposite (Nano-CE6). Study was applied on male Swiss albino mice, implanted with Ehrlich tumor (EAC) divided into six groups. Two energy sources were used; laser and Ultrasound. Results showed that Nano-CE6 is a potential sensitizer for photodynamic or sonodynamic treatment of tumor. Nano-CE6 plays an important role in tumor growth inhibition and cell death induction. Activated Nano-CE6 with both infrared laser and ultrasound has a potential antitumor effect. The results indicated that (FA–NGO–CE6) could be used as a unique nanocomposite for cancer targeted therapy SPDT.