A case of Systemic Lupus Erythematosus with class IV nephritis in a 60 year old female

Abstract

Patients who develop Systemic Lupus Erythematous (SLE) at or after the age of 50 years are considered as late-onset SLE. In this case report, we present a case of class IV Lupus Nephritis in a 60-year-old lady with newly diagnosed SLE. This lady presented with generalized edema and reduced urine output and found to have active urinary sediment, rising serum creatinine, positive ANA and dsDNA and hypocomplementemia. Renal biopsy proved diffuse proliferative glomerulonephritis (Lupus Nephritis – class IV). She was treated with methyl prednisolone and cyclophosphamide as the induction regime. Then treatment was continued according to Euro- Lupus Protocol. She showed clinical and biochemical improvement.