Fuzzy rule based unsupervised approach for salient gene extraction

Abstract

This paper presents a novel fuzzy rule based gene ranking algorithm for extracting salient genes from a large set of microarray data which helps us to reduce computational efforts towards model building process. The proposed algorithm is an unsupervised approach and does not require class information for gene ranking and Microarray data has been used to form a set of robust fuzzy rule base which helps us to find salient genes based on its average relevance with already formed fuzzy rules in rule base. Fuzzy rule based ranking has been carried out to select salient genes based on their average firing strength in order of high relevancy and only top ranked genes are utilized to classify normal and cancerous tissues for a carcinoma dataset [1]. Result validate the effectiveness of our gene ranking method as for the same no. of genes, our ranking scheme helps to improve the classifier performance by selecting better salient genes.