Electrical and viscoelastic measurement of cancer cells in epithelial-mesenchymal transition process on a microfluidic device

Yajun Yang, Bing Chen, Shaokang Meng, Shuaiyi Li, Xiaonan Yang
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引用次数: 1

Abstract

Microfluidic devices and electrical techniques based on electrical impedance and viscoelastic changes can be used in the measurement of cancer cells in the epithelial-mesenchymal transition (EMT) process. Electrical impedance and transmission time were investigated when a single CRC cell passed the measurable tiny channel which was designed with width smaller than the average diameter of a single cell. The experimental data showed that the electrical impedance characteristics and viscoelasticity of the cells were changed after PMA induction. This property is expected to become a new biomarker for studying EMT.
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微流控装置上癌细胞上皮-间质转化过程的电和粘弹性测量
基于电阻抗和粘弹性变化的微流控装置和电技术可用于癌细胞上皮-间质转化(EMT)过程的测量。研究了单个CRC细胞通过可测微通道时的电阻抗和传输时间,该微通道的宽度小于单个细胞的平均直径。实验数据表明,PMA诱导后电池的电阻抗特性和粘弹性发生了变化。该特性有望成为研究EMT的一种新的生物标志物。
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