[The immunochemical mechanisms of body adaptation to a chemical environment].

I E Kovalev, N V Shipulina
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Abstract

For the first time the dynamics of metabolic and immune responses to xenobiotics were analyzed in their long-term effect on the organism. It was shown that the organism gradually lost the capacity to respond to xenobiotics with the induction of hepatic cytochrome P450 and immune response. Possible mechanisms of this phenomenon are under consideration.

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[机体适应化学环境的免疫化学机制]。
首次分析了外源药物对机体长期影响的代谢和免疫反应动力学。结果表明,随着肝细胞色素P450和免疫应答的诱导,机体逐渐丧失了对外源药物的应答能力。这一现象的可能机制正在考虑之中。
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