Chapter 6. Polymers in Biofabrication and 3D Tissue Modelling

Abstract

Biofabrication and 3D tissue modelling without employing polymers is near-unthinkable. The vast majority of biomaterials used in this field are polymeric in nature, and range from hard, synthetic polymers for structural integrity and mechanical support, to soft, water-swollen naturally-derived hydrogels that mimic the extracellular matrix and provide biochemical cues to encapsulated cells. This chapter aims to provide insights on the use of polymer biomaterials for biofabrication and 3D tissue modelling, going beyond an exhibit of examples found in literature. Its main focus is to elucidate how polymer properties govern their behaviour in the context of biofabrication and 3D tissue modelling, and to explain the functions they serve. This will not only explain why certain polymer biomaterials have been employed so far, but it will also guide future material selection and development towards specific applications.