Blind Source Separation In Dynamic Cell Imaging Using Non-Negative Matrix Factorization Applied To Breast Cancer Biopsies

Abstract

We propose a method to fully exploit the dynamic signal produced by a recently developed non-invasive imaging modality: Dynamic Cell Imaging based on Full Field Optical Coherence Tomography, towards fast extemporaneous tissue assessment. The non-negative matrix factorisation method is used in an interpretable and quantifiable fashion to extract the signals coming from different structures of breast tissue in order to characterize cancerous tissue.