{"title":"The Development and Applications of Preparative-Scale Continuous Chromatography","authors":"P. Barker, G. Ganetsos","doi":"10.1080/01496398708057625","DOIUrl":null,"url":null,"abstract":"Abstract The scaling up of continuous chromatography to production scale is considered. The various continuous countercurrent and crosscurrent chromato-graphic techniques have been reviewed and judged according to their merits. The latest developments on a preparative/production scale semicontinuous chroma-tographic refiner (SCCR), consisting of 12 columns each of 5.4 cm i.d. × 75 cm long and packed with calcium charged resin, are reported. When the production of high fructrose corn syrup was carried out using industrial barley syfup, product throughputs of 32.3 kg sugar solids/m3 resin/h were obtained, the fructose-rich product purity was over 90% with a concentration of 12.96% w/v, and glucose-rich product contained only 6.69% fructose and had a concentration of 25.4% w/v. The computer simulation of the SCCR's operation is reported, and a good fit with experimental data was obtained.","PeriodicalId":184327,"journal":{"name":"Preparative-Scale Chromatography","volume":"25 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Preparative-Scale Chromatography","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/01496398708057625","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Abstract The scaling up of continuous chromatography to production scale is considered. The various continuous countercurrent and crosscurrent chromato-graphic techniques have been reviewed and judged according to their merits. The latest developments on a preparative/production scale semicontinuous chroma-tographic refiner (SCCR), consisting of 12 columns each of 5.4 cm i.d. × 75 cm long and packed with calcium charged resin, are reported. When the production of high fructrose corn syrup was carried out using industrial barley syfup, product throughputs of 32.3 kg sugar solids/m3 resin/h were obtained, the fructose-rich product purity was over 90% with a concentration of 12.96% w/v, and glucose-rich product contained only 6.69% fructose and had a concentration of 25.4% w/v. The computer simulation of the SCCR's operation is reported, and a good fit with experimental data was obtained.
摘要:研究了连续色谱法生产规模的扩大。对各种连续逆流色谱技术和横流色谱技术的优缺点进行了综述和评价。本文报道了制备/生产规模半连续色谱精炼厂(SCCR)的最新进展，该精炼厂由12个柱组成，每个柱长5.4 cm × 75 cm，填充有充钙树脂。以工业大麦糖浆为原料生产高果糖玉米糖浆，产糖量为32.3 kg /m3树脂/h，富果糖产品纯度为90%以上，浓度为12.96% w/v，富葡萄糖产品果糖含量仅为6.69%，浓度为25.4% w/v。对SCCR的工作进行了计算机模拟，结果与实验数据吻合较好。
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