Improved Sensitivity and Imaging Speeds of Fluorescent Imaging Using Silicon Photomultipliers

Abstract

Photomultiplier tubes (PMTs) are the standard for high sensitivity detection of fluorescence signals, but are costly, fragile, have limited QE and worse sensitivity at far-red wavelengths. Newer detectors based on silicon photomultiplier (SiPM) technology can greatly improve sensitivity and imaging rates. The advantages and utilization of silicon photomultiplier technology for high sensitivity and high-speed imaging are reviewed.