Analysis of the role of Transforming Growth Factor Beta (TGF-B) Receptors in Colorectal Cancer (CRC)-A bio-molecular networking approach

Abstract

Colorectal cancer is a type of cancer which affects colon and rectum and it is one among the prominent cause of mortality due to cancer. Drugs are developed to cure colorectal cancer after rigorous process of clinical trials, but efficiency of drug or survival rate remains low. Analysis of interactions between proteins and drugs through network study helps in discovering uncovered interaction between proteins in a pathway. Colorectal cancer can affect the digestive tract lower end can begin with non-cancerous polyps with no symptoms, but these polyps can be detected by screening. The symptoms may vary from person to person depends upon the location of cancer, some may affect with irregular bowel habits, blood in stool, and abdominal irritation. The treatment of cancer also banks on the location of cancer which includes removal of tumor, surgery or radiation and chemotherapy. Proposed approach describes about cytoscape analysis in the genes. Analysis explores the inhibition of protein present in the TGB which can prevent the tumor in the network.